VKTX efficacy/tolerability vs tirzepatide

biotech-1953, you wrote:

Partially and let me explain. It is believed that VK2735 is distinct from tirzepatide (TRZ) with similar/slightly more potent binding to GIP and 2-3x more potent binding to GLP-1 and that is a good start. (GLP1 is believed to be the prime driver for improvement in things like inflammation and so better GLP1 binding is really important.) But probably the number one reason for VK2735 superior to tirzepatide is half life (the drug stays in your system longer all the while doing what it does better than TRZ so you need less). Now I don't want to get into a debate about the definition of half life and what the actual numbers are but will state my opinion is that the MEAN half life of VK2735 is 2 times + longer than the mean half life of tirzepatide. So not only does it do a better job of binding to GLP1 (and GIP) than TRZ, it stays in your system 2 times longer. This is the main reason you need only half as much IMO.

Looking at the data is the real tell. Different titration schedules make comparisons of amounts difficult. I've done my own comparisons and IMO you need less VK2735 than TRZ.

My English was confusing before when I said "you need less 1/3 to 1/2 the API". I meant one third less to half as much TRZ. Let me be really clear this time and focus on what I really think is is. I think its half (and at worst 1/3 LESS API). So 1 gram of VK2735 is equal to 2 grams of TRZ (or at worst 1.5 gram of TRZ if its approx. one third less) to get "equivalent weight loss" IMO.

The efficacy superiority of VK2735 has multiple read throughs:

I want to stress that I've stated a lot of opinion in this post. There are multiple data points and people will no doubt reach conclusions that are different than mine. That's fine by me as I could be wrong. In the end, I expect VK2735 to be recognized as clearly superior to TRZ when approved, just like TRZ is recognized as being clearly superior to semaglutide today. Will this translate to market success? I think so but others may have differing opinions.

(I've probably said all I care to on this topic for now and encourage others to either agree or disagree if they care to.)